| NanoMn®_COVID-19 A Prospective, Multicenter, Randomized, Placebo-controlled, Parallel-group, Double-blind Trial to Evaluate the Clinical Efficacy of NanoManganese® on Top of Standard of Care, in Adult Patients With Moderate to Severe Coronavirus Disease 2019 (COVID-19) (NCT05451654) | Medesis Pharma SA | 2022-02-04 |
| Evaluation of the Safety and Immunogenicity of SII Vaccine Constructs Based on the SARS-CoV-2 (COVID-19) Variant in Adults (NCT05029856) | Novavax | 2022-02-04 |
| A Study to Evaluate the Safety and Tolerability of ALN-APP in Patients With EOAD (NCT05231785) | Alnylam Pharmaceuticals | 2022-02-04 |
| A Research Study Looking at the Comparability of 2 Different Forms of Oral Semaglutide in Healthy People (NCT05227196) | Novo Nordisk A/S | 2022-02-04 |
| HIV Vaccine in HIV-uninfected Adults (NCT04658667) | U.S. Army Medical Research and Development Command | 2022-02-03 |
| CBD for Chronic Radicular Pain on Chronic Opioid Therapy (COT) (NCT04760613) | NYU Langone Health | 2022-02-03 |
| Investigate Bioequivalence of Alpelisib Granule and Film-coated Tablet Formulation and the Food Effect of Alpelisib Granule Formulation in Adult Healthy Volunteers (NCT05195892) | Novartis Pharmaceuticals | 2022-02-03 |
| A Study of JNJ-42847922 (Seltorexant) in Healthy Participants (NCT05236868) | Janssen Research & Development, LLC | 2022-02-03 |
| A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Melanoma (Morpheus-Melanoma) (NCT05116202) | Hoffmann-La Roche | 2022-02-02 |
| PK Study to Assess Drug-drug Interaction Between Sitravatinib and a P-gp Inducer and an Inhibitor. (NCT05255276) | Mirati Therapeutics Inc. | 2022-02-02 |
| Bioequivalence Study of Different Aprocitentan Tablet Formulations (NCT05196399) | Idorsia Pharmaceuticals Ltd. | 2022-02-02 |
| Study of Pembrolizumab Combined With Decitabine and Pralatrexate in PTCL and CTCL (NCT03240211) | University of Virginia | 2022-02-02 |
| XmAb18968 (CD3-CD38) in Relapsed or Refractory Acute Leukemia and T Cell Lymphoblastic Leukemia (NCT05038644) | Ehab L Atallah | 2022-02-02 |
| Bispecific PSMAxCD3 Antibody CC-1 in Patients With Squamous Cell Carcinoma of the Lung (NCT04496674) | German Cancer Research Center | 2022-02-02 |
| A Pharmacokinetics and Safety Study of BIIB132 in Adults With Spinocerebellar Ataxia 3 (NCT05160558) | Biogen | 2022-02-02 |
| Study Comparing Pharmacokinetics of Different Formulations of Evobrutinib in Healthy Participants (NCT05245396) | Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany | 2022-02-02 |
| Testing the Combination of ZEN003694 and Nivolumab With or Without Ipilimumab in Solid Tumors (NCT04840589) | National Cancer Institute (NCI) | 2022-02-02 |
| First in Human Study of TORL-2-307-ADC in Participants With Advanced Cancer (NCT05156866) | TORL Biotherapeutics, LLC | 2022-02-02 |
| A Dose-escalation Study of the Safety and Pharmacology of DAN-222 in Subjects With Metastatic Breast Cancer (NCT05261269) | Dantari, Inc. | 2022-02-02 |
| A Study of a Single Ascending Dose Study of DS-7011a in Healthy Subjects (NCT05203692) | Daiichi Sankyo | 2022-02-02 |
| Study of the Effect of Food Intake on the Bioavailability of XC8 10 mg Film-coated Tablets (NCT05294250) | Valenta Pharm JSC | 2022-02-01 |
| Evaluate the Safety, Tolerability and Pharmacokinetic Profile of TPN672 Tablets Maleate in Patients With Schizophrenia (NCT05192304) | Jiangsu Kanion Pharmaceutical Co., Ltd | 2022-02-01 |
| Single Arm Study of Post-transplant Azacitidine and Chidamide for Prevention of Acute Myelogenous Leukemia Relapse (NCT05270200) | Zhujiang Hospital | 2022-02-01 |
| A Study to Evaluate the Tolerability, Safety, Pharmacokinetics, and Antitumor Activity of Loncastuximab Tesirine in Combination With Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated Diffuse Large B-cell Lymphoma (LOTIS-8) (NCT04974996) | ADC Therapeutics S.A. | 2022-02-01 |
| Electrical Brain Stimulation for Cognitive Impairment in Schizophrenia: a tDCS-fMRI Study (NCT05200962) | The National Brain Mapping Laboratory (NBML) | 2022-02-01 |
| [18F]MC225-PET in Neurodegenerative Disease (NCT05853471) | University Medical Center Groningen | 2022-02-01 |
| Clinical Study to Evaluate the Tolerability and Pharmacokinetics of TQB2916 Injection in Patients With Advanced Malignant Tumors (NCT05213767) | Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd. | 2022-02-01 |
| Use of Direct Peritoneal Resuscitation in High-risk Liver Transplant Recipients (NCT05195125) | University of Colorado, Denver | 2022-02-01 |
| Optiflow vs. Convential Anesthesia During Pediatric Laryngeal Papilloma Removal (NCT05215249) | Massachusetts Eye and Ear Infirmary | 2022-02-01 |
| A Study to Assess the Pharmacokinetic (PK) Comparability of 2 Fixed Subcutaneous (SC) Doses of Aducanumab (BIIB037) With a Single, Weight-Based Intravenous (IV) Dose in Healthy Volunteers (NCT05216887) | Biogen | 2022-02-01 |
| Beta 3 Agonists in Treatment of Non-neurogenic Voiding Dysfunction in Children (NCT05240456) | Mansoura University | 2022-02-01 |
| Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cell Intravenous Infusion for CP (NCT05018819) | The Foundation for Orthopaedics and Regenerative Medicine | 2022-02-01 |
| Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cells for Heart Disease (NCT05147766) | The Foundation for Orthopaedics and Regenerative Medicine | 2022-02-01 |
| Acetazolamide for Treatment Resistant Schizophrenia (NCT04887792) | Vishwajit Nimgaonkar, MD PhD | 2022-02-01 |
| Small Changes Behavioural Weight Loss Treatment Approach for Psoriatic Arthritis Patients With Comorbid Obesity (NCT05225623) | University of Calgary | 2022-02-01 |
| Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cells for NAION (NCT05147701) | The Foundation for Orthopaedics and Regenerative Medicine | 2022-02-01 |
| Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cell Exosome Intranasal Instillations for Stroke (NCT05158101) | The Foundation for Orthopaedics and Regenerative Medicine | 2022-02-01 |
| Ketamine + Mindfulness for Depression (NCT05168735) | Rebecca Price | 2022-02-01 |
| Effect of Arterio-venous ECMO on Severe Sepsis and ARDS (NCT04555798) | Mohamed Gaber Allam | 2022-02-01 |
| Study of ARO-C3 in Adult Healthy Volunteers and Patients With Complement Mediated Renal Disease (NCT05083364) | Arrowhead Pharmaceuticals | 2022-02-01 |
| Study of Ossium Mesenchymal Stem Cells for the Treatment of Pouch Fistulas in the Setting of Crohn's Disease (NCT05075811) | Anthony Lembo | 2022-02-01 |
| Ketodex Versus Opioid Based Anaesthesia in Cleft Palate Repair Ketodex Versus Opioid Based Anaesthesia in Cleft Palate Repair Ketodex Versus Opioid Based Anaesthesia in Cleft Palate Repair Ketodex Versus Opioids in Cleft Palate Repaire (NCT05402189) | Ain Shams University | 2022-02-01 |
| A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DNL593 in Healthy Participants and Participants With Frontotemporal Dementia (FTD-GRN) (NCT05262023) | Denali Therapeutics Inc. | 2022-02-01 |
| A Study of TDM-105795 in Male Subjects With Androgenetic Alopecia (AGA) (NCT05244980) | Technoderma Medicines Inc. | 2022-02-01 |
| The Effect of Arabica Gayo Cascara Pulp Extract on Photoaging (NCT05390489) | Wahyu Lestari | 2022-02-01 |
| Microbiome Derived Metabolism and Pharmacokinetics (NCT05065671) | Rutgers, The State University of New Jersey | 2022-02-01 |
| A Study of Anvumetostat in Participants With Advanced MTAP-null Solid Tumors (MTAPESTRY 101) (NCT05094336) | Amgen | 2022-02-01 |
| Safety and Preliminary Efficacy of Meldonium in Patients with Metastatic Renal Cell Carcinoma and Treatment-associated Fatigue (NCT06648902) | Kidney Cancer Research Bureau | 2022-02-01 |
| Comparison of Nicotinamide Treatments for Actinic Keratosis (NCT07049068) | Federal University of Rio Grande do Sul | 2022-02-01 |
| Angiotensin (1-7) for the Treatment of COVID-19 in Hospitalized Patients (NCT04570501) | Stanford University | 2022-02-01 |
| Ulinastatin for the Treatment of COVID-19 in Hospitalized Patients (NCT04393311) | Stanford University | 2022-02-01 |
| Intraperitoneal Paclitaxel for Patients With Primary Malignant Peritoneal Mesothelioma (NCT05449366) | Erasmus Medical Center | 2022-02-01 |
| Mesenchymal Stem Cells Derived Exosomes in Skin Rejuvenation (NCT05813379) | Isfahan University of Medical Sciences | 2022-02-01 |
| ALT-801 in Overweight and Obese Subjects With Type 2 Diabetes Mellitus (T2DM) (NCT05134662) | Altimmune, Inc. | 2022-02-01 |
| Study to Assess Signature Cord Product in Patients With Symptomatic OA of the Knee (NCT05234489) | Thomas Klootwyk, MD | 2022-02-01 |
| Safety and Immune Response to FMPV-1 (NCT05238558) | Hubro Therapeutics AS | 2022-01-31 |
| Proof of Mechanism Study to Evaluate Binding of Alfa-synuclein (NCT05274568) | Invicro | 2022-01-31 |
| A Phase 1/2a Study of DB-1303/BNT323 in Advanced/Metastatic Solid Tumors (NCT05150691) | DualityBio Inc. | 2022-01-31 |
| Gene Therapy Study for Children With CLN5 Batten Disease (NCT05228145) | Neurogene Inc. | 2022-01-31 |
| Feasibility of the Adapted H-GRASP Feedback Program in the Chronic Phase Post Stroke. (NCT05227521) | KU Leuven | 2022-01-31 |
| A STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF MULTIPLE SUBCUTANEOUS INJECTIONS OF SHR-1819 IN PATIENTS WITH MODERATE TO SEVERE ATOPIC DERMATITIS (NCT05197023) | Shanghai Hengrui Pharmaceutical Co., Ltd. | 2022-01-30 |
| A Trial of ATG-101 in Patients With Metastatic/Advanced Solid Tumors and Mature B-cell Non-Hodgkin Lymphomas (NCT05490043) | Antengene (Hangzhou) Biologics Co., Ltd. | 2022-01-30 |
| 177Lu-DOTA-TLX591 Safety, Biodistribution and Dosimetry Study (NCT04786847) | Telix Pharmaceuticals (Innovations) Pty Limited | 2022-01-30 |
| A Study of Human TH-SC01 Cell Injection for Treating Perianal Fistulas in Patients With Crohn's Disease (NCT05626023) | Jiangsu Topcel-KH Pharmaceutical Co., Ltd. | 2022-01-30 |
| Phase I Clinical Study of YL-15293 in Patients With Advanced Solid Tumor With KRAS Mutation (NCT05173805) | Shanghai YingLi Pharmaceutical Co. Ltd. | 2022-01-30 |
| Safety and Pharmacokinetics of Orodispersible BT-11 in Active Eosinophilic Esophagitis (NCT04835168) | NImmune Biopharma | 2022-01-30 |
| A Study of EDP-235 in Healthy Subjects (NCT05246878) | Enanta Pharmaceuticals, Inc | 2022-01-28 |
| A Study Investigating agenT-797 in Participants With Relapsed/Refractory Solid Tumors (NCT05108623) | MiNK Therapeutics | 2022-01-28 |
| Establishing a Controlled Human Infection Model of Bordetella Pertussis (NCT05136599) | Dalhousie University | 2022-01-28 |
| CBL0137 for the Treatment of Relapsed or Refractory Solid Tumors, Including CNS Tumors and Lymphoma (NCT04870944) | Children's Oncology Group | 2022-01-28 |
| Combination of Fedratinib and Decitabine for Myeloproliferative Neoplasms (MPN)- Accelerated Phase (AP)/Blast Phase (BP) (NCT05524857) | Joseph Jurcic | 2022-01-28 |
| Chlorpromazine and Standard of Care in Glioblastoma (NCT05190315) | Mohammed Milhem | 2022-01-28 |
| NPI-002 Intravitreal Implant for the Delay of Cataract Progression (NCT05026632) | Nacuity Pharmaceuticals, Inc. | 2022-01-27 |
| Safety and Efficacy Study of Anti-B7-H3 CAR-T Cell Therapy for Recurrent Glioblastoma (NCT05241392) | Beijing Tiantan Hospital | 2022-01-27 |
| A Study of Azenosertib (ZN-c3) and Niraparib in Subjects With Platinum-Resistant Ovarian Cancer (NCT05198804) | K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc | 2022-01-27 |
| An Exploratory Clinical Trial to Evaluate and Compare Safety and Pharmacokinetic Characteristics After Administration of the DWJ1439, DWJ1464, DWC202108 or DWC202109 in Healthy Adult Volunteers (NCT05832697) | Daewoong Pharmaceutical Co. LTD. | 2022-01-27 |
| ESP Block VS Intrathecal Opioid After Laparoscopic Colorectal Surgery (NCT05257941) | Indiana University | 2022-01-27 |
| Focused Ultrasound and Gemcitabine in Breast Cancer (NCT04796220) | Patrick Dillon, MD | 2022-01-27 |
| Ablation of Arteries for the Treatment of Type 2 Diabetes Mellitus and Its Comorbidities (NCT05369065) | Neurotronic, Inc. | 2022-01-27 |
| Study of 111In-XYIMSR-01 SPECT/CT in Patients With Metastatic Clear Cell Renal Cell (NCT07062549) | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 2022-01-26 |
| Decitabine/Cedazuridine and Enzalutamide for the Treatment of Metastatic Castrate Resistant Prostate Cancer (NCT05037500) | Roswell Park Cancer Institute | 2022-01-26 |
| A Study to Test How Well Healthy Men Tolerate BI 765250 When Given as an Infusion Into the Vein or as an Injection Under the Skin (NCT05151653) | Boehringer Ingelheim | 2022-01-26 |
| Clinical Trial to Evaluate the Safety, Tolerability and Efficacy of CT303 in Patients With ARDS (NCT05238532) | GC Cell Corporation | 2022-01-26 |
| Pilot Study Characterizing the Pharmacokinetic Profile of a Novel Encapsulated Caffeine Beverage in the Fed and Fasted States (NCT05266248) | PepsiCo Global R&D | 2022-01-25 |
| Study to Evaluate the Safety, Tolerability, PDs, and Efficacy of CNP-104 in Subjects With Primary Biliary Cholangitis (NCT05104853) | COUR Pharmaceutical Development Company, Inc. | 2022-01-25 |
| A Study to Evaluate Safety, Pharmacokinetics, and Preliminary Anti-tumor Activity of RO7444973 in Participants With Unresectable and/or Metastatic MAGE-A4-positive Solid Tumors (NCT05129280) | Hoffmann-La Roche | 2022-01-25 |
| Extension Study in a Cohort of Adult Patients With COVID-19 Infection (NCT05121740) | PharmaMar | 2022-01-25 |
| A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of SKI-G-801 in Patients With Advanced Solid Tumors (NCT05971862) | Oscotec Inc. | 2022-01-25 |
| Testing a New Immune Cell Therapy, GD2-Targeted Modified T-cells (GD2CART), in Children, Adolescents, and Young Adults With Relapsed/Refractory Osteosarcoma and Neuroblastoma, GD2-CAR PERSIST Trial (NCT04539366) | National Cancer Institute (NCI) | 2022-01-25 |
| Pharmacokinetics of Sotrovimab as Pre-exposure Prophylaxis for COVID-19 in Hematopoietic Stem Cell Transplant Recipients, COVIDMAB Study (NCT05135650) | Fred Hutchinson Cancer Center | 2022-01-25 |
| Maintenance Ipilimumab + Nivolumab Post Induction Chemotherapy + SBRT for First Line Treatment Stage IV Pancreatic Cancer (NCT05088889) | Sheba Medical Center | 2022-01-25 |
| Study of STK-012 Alone and With Other Treatments in Patients With Advanced Lung Cancer and Other Cancers (NCT05098132) | Synthekine | 2022-01-25 |
| Trifluridine/Tipiracil in Combination With Capecitabine and Bevacizumab in Metastatic Colorectal Cancer Patients. (NCT04564898) | Gruppo Oncologico del Nord-Ovest | 2022-01-25 |
| Drug-drug Interactions Between DZD9008 and Itraconazole/Carbamazepine (NCT05418582) | Dizal Pharmaceuticals | 2022-01-25 |
| Study of VAY736 as Single Agent and in Combination With Select Antineoplastic Agents in Patients With Non-Hodgkin Lymphoma (NCT04903197) | Novartis Pharmaceuticals | 2022-01-24 |
| Study of NIB101 in Participants With Advanced Solid Tumors (NCT05192174) | Noile-Immune Biotech, Inc | 2022-01-24 |
| To Evaluate KC1036 in the Patients with Advanced Digestive System Tumors (NCT05260385) | Beijing Konruns Pharmaceutical Co., Ltd. | 2022-01-24 |
| Study to Assess the Safety and Efficacy of OCU400 for Retinitis Pigmentosa and Leber Congenital Amaurosis (NCT05203939) | Ocugen | 2022-01-24 |
| TACE Plus Axitinib and Hydroxychlorquine for Liver-Dominant Metastatic Colorectal Cancer (CRC) (NCT04873895) | Abramson Cancer Center at Penn Medicine | 2022-01-24 |
| Gabapentin & Ketamine for Prevention/Treatment of Acute/Chronic Pain in Locally Advanced Head and Neck Cancer (NCT05156060) | Natalie Lockney | 2022-01-24 |